Single-Molecule Counting of Point Mutations by Transient DNA Binding
نویسندگان
چکیده
منابع مشابه
Single-Molecule Counting of Point Mutations by Transient DNA Binding
High-confidence detection of point mutations is important for disease diagnosis and clinical practice. Hybridization probes are extensively used, but are hindered by their poor single-nucleotide selectivity. Shortening the length of DNA hybridization probes weakens the stability of the probe-target duplex, leading to transient binding between complementary sequences. The kinetics of probe-targe...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep43824